Head to Head
| NFL | 2018/12/16 18:00 | DET Lions v BUF Bills | W | 13-14 |
| Preseason NFL | 2017/08/31 23:00 | BUF Bills v DET Lions | W | 27-17 |
| Preseason NFL | 2016/09/01 23:30 | DET Lions v BUF Bills | L | 31-0 |
| NFL | 2014/10/05 17:00 | DET Lions v BUF Bills | W | 14-17 |
Home History
| Preseason NFL | 2019/08/16 23:00 | BUF Bills v CAR Panthers | W | 27-14 |
| Preseason NFL | 2019/08/08 23:00 | IND Colts v BUF Bills | W | 16-24 |
| NFL | 2018/12/30 18:00 | MIA Dolphins v BUF Bills | W | 17-42 |
| NFL | 2018/12/23 18:00 | BUF Bills v NE Patriots | L | 12-24 |
| NFL | 2018/12/16 18:00 | DET Lions v BUF Bills | W | 13-14 |
| NFL | 2018/12/09 18:00 | NY Jets v BUF Bills | L | 27-23 |
| NFL | 2018/12/02 18:00 | BUF Bills v MIA Dolphins | L | 17-21 |
| NFL | 2018/11/25 18:00 | JAX Jaguars v BUF Bills | W | 21-24 |
Away History
| Preseason NFL | 2019/08/18 00:00 | DET Lions v HOU Texans | L | 23-30 |
| Preseason NFL | 2019/08/08 23:30 | NE Patriots v DET Lions | L | 31-3 |
| NFL | 2018/12/30 18:00 | DET Lions v GB Packers | W | 31-0 |
| NFL | 2018/12/23 18:00 | MIN Vikings v DET Lions | L | 27-9 |
| NFL | 2018/12/16 18:00 | DET Lions v BUF Bills | L | 13-14 |
| NFL | 2018/12/09 21:25 | DET Lions v ARZ Cardinals | W | 17-3 |
| NFL | 2018/12/02 18:00 | LA Rams v DET Lions | L | 30-16 |
| NFL | 2018/11/22 17:30 | CHI Bears v DET Lions | L | 23-16 |
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