stadio: First Security Field at Estes Stadium Round: 1
Home Manager: Nathan Brown Away Manager: Bobby Petrino
| NCAAF | 2021/09/12 00:00 | Central Arkansas v Missouri St | W | 34-43 |
| NCAAF | 2020/10/18 00:00 | Central Arkansas v Missouri St | L | 33-24 |
| NCAAF | 2020/09/27 00:00 | Missouri St v Central Arkansas | L | 20-27 |
| NCAAF | 2021/11/27 21:00 | Tennessee Martin v Missouri St | L | 32-31 |
| NCAAF | 2021/11/21 02:00 | Missouri St v Utah Tech | W | 55-24 |
| NCAAF | 2021/11/13 20:00 | Northern Iowa v Missouri St | W | 27-34 |
| NCAAF | 2021/11/06 17:00 | Missouri St v SO Illinois | W | 38-28 |
| NCAAF | 2021/10/30 19:00 | North Dakota v Missouri St | W | 28-32 |
| NCAAF | 2021/10/23 19:30 | Missouri St v North Dakota State | L | 20-27 |
| NCAAF | 2021/10/16 19:00 | Indiana State v Missouri St | W | 7-37 |
| NCAAF | 2021/10/09 18:00 | Missouri St v Youngstown State | L | 33-41 |
| NCAAF | 2021/11/21 00:00 | Central Arkansas v Tarleton State | L | 3-24 |
| NCAAF | 2021/11/13 22:00 | Stephen F. Austin v Central Arkansas | L | 27-14 |
| NCAAF | 2021/11/06 21:00 | Central Arkansas v Texas Wesleyan Rams | W | 63-3 |
| NCAAF | 2021/10/30 18:00 | Central Arkansas v Jacksonville State | W | 38-14 |
| NCAAF | 2021/10/23 23:00 | Central Arkansas v Lamar | W | 49-38 |
| NCAAF | 2021/10/16 21:00 | Eastern Kentucky v Central Arkansas | L | 38-35 |
| NCAAF | 2021/10/02 23:00 | Central Arkansas v Abilene Christian | W | 42-21 |
| NCAAF | 2021/09/25 21:00 | Sam Houston State v Central Arkansas | L | 45-35 |