| Challenger Drummondville | 03/14 19:55 | 26 | [219] John-Patrick Smith v Roberto Cid Subervi [249] | 7-6,5-7,3-6 | |
| Challenger Drummondville | 03/12 23:05 | 25 | John-Patrick Smith v Liam Draxl | 6-7,7-5,7-6 | |
| Challenger Indian Wells | 02/26 20:45 | 25 | [112] Andrey Rublev v John-Patrick Smith [225] | 6-2,7-5 | |
| Challenger Indian Wells | 02/25 20:10 | 24 | [225] John-Patrick Smith v Noah Rubin [152] | 6-7,6-3,6-4 | |
| ATP Delray Beach | 02/16 21:20 | 64 | [217] John-Patrick Smith v Darian King [164] | 4-6,6-7 | |
| Australian Open | 01/08 23:00 | 44 | [202] John-Patrick Smith v Matthias Bachinger [129] | 5-7,3-6 | |
| ATP Brisbane | 12/29 01:15 | 64 | [77] Taro Daniel v John-Patrick Smith [199] | 3-6,6-4,6-4 | |
| Open d'Australia - Wild Card | 12/11 23:00 | 27 | [265] Maverick Banes v John-Patrick Smith [200] | 6-4,6-7,1-6,6-0,6-2 | |
| Open d'Australia - Wild Card | 12/09 23:00 | 26 | [467] Jeremy Beale v John-Patrick Smith [200] | 2-6,5-7,7-5,3-6 | |
| Challenger Champaign | 11/15 19:55 | 27 | Ryan Shane v John-Patrick Smith | 7-5,6-1 | |
| Challenger Champaign | 11/14 18:30 | 26 | [472] Takanyi Garanganga v John-Patrick Smith [209] | 3-6,4-6 | |
| Challenger Champaign | 11/12 23:00 | 25 | [303] Denis Yevseyev v John-Patrick Smith [209] | 3-6,6-7 | |
| Challenger Knoxville | 11/07 00:05 | 25 | [140] Tim Smyczek v John-Patrick Smith [202] | 3-6,6-3,6-2 | |
| Challenger Las Vegas | 10/27 17:30 | 28 | [235] John-Patrick Smith v Blaz Rola [262] | 3-6,5-7 | |
| Challenger Las Vegas | 10/26 18:00 | 27 | [235] John-Patrick Smith v Jason Jung [127] | 7-6,6-3 | |
| Challenger Las Vegas | 10/25 18:00 | 26 | [235] John-Patrick Smith v Cem Ilkel [233] | 6-3,6-1 | |
| Challenger Las Vegas | 10/23 20:10 | 25 | [267] Jelle Sels v John-Patrick Smith [235] | 7-6,5-7,4-6 | |
| Challenger Las Vegas | 10/23 20:05 | 25 | Reilly Opelka v John-Patrick Smith | Cancelled | |
| Challenger Calgary | 10/17 21:40 | 26 | [325] Enzo Couacaud v John-Patrick Smith [242] | 7-5,7-5 | |
| Challenger Calgary | 10/17 16:00 | 25 | John-Patrick Smith v Alex Bolt | Cancelled | |
| Challenger Calgary | 10/16 19:45 | 25 | John-Patrick Smith v Tom Fawcett | 7-6,7-6 | |
| Challenger Fairfield | 10/09 22:00 | 25 | [158] Bjorn Fratangelo v John-Patrick Smith [240] | 3-6,6-2,6-4 | |
| Challenger Stockton | 10/01 21:20 | 25 | [255] Mitchell Krueger v John-Patrick Smith [236] | 3-6,6-3,6-4 | |
| Challenger Tiburon | 09/28 18:00 | 27 | [104] Marcel Granollers v John-Patrick Smith [252] | 6-2,6-3 | |
| Challenger Tiburon | 09/26 18:00 | 26 | [252] John-Patrick Smith v Bjorn Fratangelo [175] | 1-6,6-4,6-2 | |
| Challenger Tiburon | 09/25 17:00 | 25 | [252] John-Patrick Smith v Pedro Martinez [174] | 6-4,6-2 | |
| Challenger Columbus | 09/18 14:00 | 25 | [246] John-Patrick Smith v Roberto Quiroz [213] | 6-3,6-7,6-7 | |
| Challenger Chicago | 09/06 17:30 | 26 | [246] Donald Young v John-Patrick Smith [220] | 6-3,6-4 | |
| Challenger Chicago | 09/04 15:00 | 25 | [220] John-Patrick Smith v Roberto Cid Subervi [225] | 2-6,6-1,6-4 | |
| US Open | 08/21 19:10 | 44 | [109] Hubert Hurkacz v John-Patrick Smith [221] | 6-3,6-2 |