| ATP Atlanta - Qual. | 07/21 16:20 | 64 | [86] Denis Kudla v John-Patrick Smith [194] | 3-6,7-6,6-3 | |
| ATP Newport - Qual. | 07/16 17:15 | 164 | [194] John-Patrick Smith v Victor Estrella Burgos [198] | 6-3,5-7,5-7 | |
| ATP Newport - Qual. | 07/15 17:50 | 64 | [139] Marcelo Arevalo v John-Patrick Smith [211] | 1-6,7-6,5-7 | |
| Wimbledon | 07/02 14:45 | 23 | [211] John-Patrick Smith v Andreas Seppi [50] | 2-6,4-6,1-6 | |
| Wimbledon - Qual. | 06/28 10:00 | 45 | [211] John-Patrick Smith v Michael Mmoh [119] | 6-2,6-4,6-3 | |
| Wimbledon - Qual. | 06/26 17:00 | 45 | [116] Marcel Granollers v John-Patrick Smith [211] | 3-6,4-6 | |
| Wimbledon - Qual. | 06/25 15:30 | 44 | [211] John-Patrick Smith v Uladzimir Ignatik [212] | 6-7,6-1,8-6 | |
| Challenger Ilkley - Qual. | 06/17 16:30 | 46 | [173] Noah Rubin v John-Patrick Smith [196] | 7-5,7-5 | |
| Challenger Ilkley - Qual. | 06/16 18:35 | 45 | [212] Lloyd Harris v John-Patrick Smith [196] | 6-7,3-6 | |
| ATP Hertogenbosch | 06/12 10:30 | 25 | [37] Stefanos Tsitsipas v John-Patrick Smith [196] | 3-6,6-3,6-4 | |
| ATP Den Bosch - Qual. | 06/10 10:55 | 164 | [198] John-Patrick Smith v Max Purcell [216] | 4-6,6-7 | |
| ATP Den Bosch - Qual. | 06/09 08:30 | 64 | [109] Bjorn Fratangelo v John-Patrick Smith [198] | 3-6,6-7 | |
| Challenger Surbiton - Qual. | 06/02 14:10 | 45 | [334] Daniel Brands v John-Patrick Smith [198] | 6-3,6-4 | |
| Open di Francia - Qual. | 05/22 08:00 | 44 | [197] John-Patrick Smith v Corentin Denolly [427] | 3-6,6-4,4-6 | |
| Challenger Busan | 05/17 02:00 | 26 | [347] Yosuke Watanuki v John-Patrick Smith [200] | 7-6,6-4 | |
| Challenger Busan | 05/15 06:30 | 25 | Seong Chan Hong v John-Patrick Smith | 2-6,4-6 | |
| Challenger Gimcheon | 05/08 06:55 | 25 | [362] Yoshihito Nishioka v John-Patrick Smith [201] | 6-4,6-0 | |
| Challenger Leon | 04/29 17:00 | 29 | [228] John-Patrick Smith v Christopher Eubanks [246] | 4-6,6-3,6-7 | |
| Challenger Leon | 04/28 20:00 | 28 | [228] John-Patrick Smith v Alejandro Gonzalez [307] | 6-4,6-3 | |
| Challenger Leon | 04/27 19:30 | 27 | [228] John-Patrick Smith v Filip Peliwo [178] | 6-1,6-4 | |
| Challenger Leon | 04/26 19:00 | 26 | [151] Adrian Menendez-Maceiras v John-Patrick Smith [228] | 7-6,4-6,3-6 | |
| Challenger Leon | 04/24 19:35 | 25 | [298] Edan Leshem v John-Patrick Smith [228] | 6-7,0-6 | |
| Challenger Guadalajara | 04/20 23:20 | 27 | [181] Marcelo Arevalo v John-Patrick Smith [238] | 7-6,3-6,6-3 | |
| Challenger Guadalajara | 04/19 21:00 | 26 | [238] John-Patrick Smith v Filip Peliwo [180] | 3-6,6-1,6-2 | |
| Challenger Guadalajara | 04/17 22:35 | 25 | [238] John-Patrick Smith v Daniel Elahi Galan [233] | 6-2,6-7,6-1 | |
| Challenger Le Gosier | 03/30 19:00 | 27 | [235] Christian Garin v John-Patrick Smith [236] | 7-5,7-6 | |
| Challenger Le Gosier | 03/29 20:15 | 26 | [236] John-Patrick Smith v Peter Polansky [126] | 7-6,6-3 | |
| Challenger Le Gosier | 03/27 18:00 | 25 | [236] John-Patrick Smith v Akira Santillan [170] | Retired | |
| Challenger Drummondville | 03/13 16:05 | 25 | Christian Harrison v John-Patrick Smith | 6-0,6-7,7-6 | |
| ATP Delray Beach | 02/20 01:00 | 25 | Jack Sock v John-Patrick Smith | 6-4,6-4 |